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KMID : 1039920180250040191
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Neonatal Medicine
2018 Volume.25 No. 4 p.191 ~ p.195
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Leukocyte Adhesion Deficiency Associated with Neonatal Septic Hip in a Late Preterm Infant
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Kim Hye-Eun
Kim Do-Hee
Chung Sung-Hoon
Bae Chong-Woo
Choi Yong-Sung
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Abstract
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Leukocyte adhesion deficiency is a rare primary immunodeficiency and autosomal recessive disorder caused by a mutation in the gene encoding CD18, which is a constituent of leukocyte integrins. Clinical features usually begin with a delay in the separation of the umbilical cord in the neonatal period, and are characterized by marked leukocytosis with infection, delayed wound healing, and repeated bacterial and fungal infections. We experienced a case of leukocyte adhesion deficiency diagnosed in the neonatal period, in which a late preterm infant admitted to neonatal intensive care unit presented with a septic hip. Flow cytometry analysis of whole blood showed a decrease in the expression of CD11b/CD18. This is the first case of leukocyte adhesion deficiency with neonatal septic hip diagnosed in Korea.
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KEYWORD
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Leukocyte adhesion deficiency, Infectious arthritis, Osteomyelitis, Premature infant
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